Senolytic-Repair with CyanthOx™: Anti-aging

Cellular aging accelerates when senescent cells accumulate, mitochondrial output declines, oxidative stress rises, and SASP-driven inflammation persists. A phased strategy—first lowering the senescence and inflammatory burden (Senolytic), then rebuilding cellular energy, structure, and defenses (Repair)—creates the conditions for durable rejuvenation at the cellular level.

CyanthOx™ is a polyphenol-rich Sea Buckthorn extract with exceptional antioxidant capacity (ORAC 895,281 μmol TE/100 g—about 9× grape seed extract and nearly 2× French maritime pine bark). This redox power helps curb ROS/RNS, protecting DNA, proteins, and membranes, and quieting oxidative drivers of cellular aging.

Phase 1 — Senolytic: lower senescence load and SASP signaling. Senescent cells secrete pro-inflammatory SASP factors that perpetuate damage and impair function.

  • Mechanisms and results

-Anti-senescence support:

Human dermal fibroblasts: +64% cell viability and higher type I collagen in aging cells, indicating reduced senescence pressure and improved cellular structural integrity.

SASP/inflammation reduction

TNF‑α −33%, IL‑1β −33%, IL‑6 −57%, VEGF −29%, reflecting restraint of pro-inflammatory and pro-angiogenic signaling linked to senescence.

Oxidative containment

Exceptional ORAC capacity helps limit the redox loop that sustains senescent signaling and macromolecular damage.

Net effect: A cleaner intracellular environment with reduced inflammatory and oxidative stress—enabling downstream cellular repair.

Phase 2 — Repair: restore cellular energy, defenses, and renewal capacity. With the senescence burden reduced, cells can rebuild core functions essential to healthspan.

  • Mechanisms and results

-Mitochondrial revitalization

+69% mitochondrial membrane potential; +91% ATP—re-energizing cellular metabolism and lowering secondary oxidative stress.

-Endogenous defenses and structural support

SOD activity +100%, alongside increases in cellular matrix components (collagen +186%, elastin +153%, hyaluronic acid +47%) that contribute to cellular scaffold integrity and function.

-Regenerative capacity

40% increase in circulating progenitor, mesenchymal, and endothelial stem cells—supporting maintenance and repair processes at the cellular level.

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CyanthOx™ - The Strongest Plant Antioxidant

CyanthOx™ mapped to core aging mechanisms

  • Oxidative stress/genomic stability: Very high antioxidant capacity and higher SOD activity help protect DNA and proteins.

  • Mitochondrial dysfunction: Improved membrane potential and ATP restore energetic homeostasis.

  • Cellular senescence: Enhanced viability and structural protein support indicate pressure reduction on senescent pathways.

  • Stem cell exhaustion: >40% rise in circulating stem cells supports ongoing maintenance and regeneration.

  • Altered intercellular communication/chronic inflammation: Reductions in TNF‑α, IL‑1β, IL‑6, VEGF help normalize signaling landscapes relevant to cellular aging.

A clear cellular Senolytic-Repair arc with CyanthOx™

  • Clear: Reduce oxidative stress and SASP to lower senescent burden.

  • Repair: Rebuild mitochondrial energy, endogenous antioxidant systems, and cellular structural integrity.

  • Renew: Support stem cell availability to sustain cellular maintenance and repair.

CyanthOx™ synchronizes senescence control with energetic repair, endogenous defense upregulation, and regenerative support—delivering a coherent, systems-level path to healthier, longer-functioning cells.

 

CyanthOx™: A holistic beauty solution

Healthspan beauty is democratizing beauty-from-within—bringing credible, multifunctional, and enjoyable solutions into everyday life. CyanthOx™, powered by nutrient-dense sea buckthorn, nourishes cellular health for visible radiance, supports longevity pathways for graceful aging, and energizes active lifestyles—an evidence-based path to looking and feeling beautiful for the long run.

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Featured Ingredient

Strongest Plant Antioxidants: 9x Stronger than Grape Seed & Acai

100% Plant-based & Vegan
No Additives / Solvent Used
Completely soluble in water
Good Thermal & pH Stability
Patented Technology

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This ingredient is certified with:

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References

  1. Lopez-Otin et al., 2023, Cell, 186(1), 243-278.

  2. Liu et al., 2022, Frontiers in Pharmacology, 13, Article 914146.

  3. Lin et al., 2022, Frontiers in Nutrition, 9, Article 850076.

  4. Liu et al., 2022, Antioxidants, 11(11), 1900.

  5. Drapeau et al., 2019, Clinical Interventions in Aging, 14, 253-263.

  6. Y. et al., 2016, Nutrients, 8(5), p. 245.

  7. Huang et al., 2008, Journal of Chongqing Medicine University, 33(8), pp.970-1002.

  8. Huang et al, 2008, Acta Academiae Medicinae Militaris Tertiae, 30(8), pp.771-772.

  9. Huang et al, 2008, Chinese Traditional Patent Medicine, 30(5), pp.632-635.

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