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Eyes and Vision

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Cyanthox™ supports healthy retinal photo-oxidative exposure response

Design: Randomised, controlled trial was conducted in 32 rabbits weighing from 2.5kg to 3.0kg. The rabbits were exposed to light at 18,000lx for 2 hours.

Dosage: Oral intake of 100mg 38.9% sea buckthorn proanthocyanidins(SBOPC)/kg/day for 14 days before exposure and 7 days after exposure.

Result: Protective effect against visible light-induced retinal degeneration

  • Helps preserve the retinal structure

    • Significant suppression of decrease in Outer Nuclear Layer (ONL) thickness and full thickness of retina

 
CyanthOx™ is a unique sea buckthorn extract with a rich combination of  polyphenols ,  proanthocyanidins ,  bioflavonoids , which offer extensive natural health benefits.

CyanthOx™ is a unique sea buckthorn extract with a rich combination of polyphenols, proanthocyanidins, bioflavonoids, which offer extensive natural health benefits.

Outer Nuclear Layer Thickness

 

control group

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-VE Control group

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100mg SBOPC Group

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  • Attenuates damages to photoreceptor cell function

    • Significant Improvement of scotopic, photopic and max electroretinogram functions

Visual Function

Scotopic Electroretinogram

cyanthox health benefit eyes and vision scotopic.png

photopic electroretinogram

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max electroretinogram

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Conclusion: 100mg 38.9% sea buckthorn proanthocyanidins(SBOPC)/kg/day prevents retinal photo-oxidative damage related diseases

 

(Wang et al., 2016)


 

Cyanthox™ is 5 times more effective than bilberry anthocyanins extract

Design: Randomised, controlled trial was conducted in 40 healthy rabbits weighing from 2.5 to 3.0kg. The rabbits were exposed to light at 18,000lx for 2 hours.

Dosage: Oral intake of 500mg 41.0% bilberry anthocyanins(BAE)/kg/day for 14 days before exposure and 7 days after exposure.

Result: 500mg 41% bilberry anthocyanins shows similar effects as 100mg 38.9% sea buckthorn proanthocyanidins.

  • The same level of reduction in Outer Nuclear Layer (ONL) thickness

  • 9% more Improvement in photopic electroretinogram functions

  • Similar Improvement in scotopic and max electroretinogram functions

ONL Comparison

CyanthOx Eyes and Vision SBOPC BAE Comparison ONL.png

Photopic Electroretinogram

CyanthOx Eyes and Vision SBOPC BAE Comparison Photopic.png
 

Conclusion: Sea buckthorn proanthocyanidins is 5.3 times more potent than bilberry anthocyanin

 

(Wang et al., 2015)


Reference

  1. Wang, Y., Zhao, L., Huo, Y., Zhou, F., Wu, W., Lu, F., Yang, X., Guo, X., Chen, P., Deng, Q. and Ji, B. (2016). Protective Effect of Proanthocyanidins from Sea Buckthorn (Hippophae Rhamnoides L.) Seed against Visible Light-Induced Retinal Degeneration in Vivo. Nutrients, [online] 8(5), p.245. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882658/.

  2. Wang, Y., Zhao, L., Lu, F., Yang, X., Deng, Q., Ji, B. and Huang, F. (2015). Retinoprotective Effects of Bilberry Anthocyanins via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms in a Visible Light-Induced Retinal Degeneration Model in Pigmented Rabbits. Molecules, [online] 20(12), pp.22395-22410. Available at: https://www.ncbi.nlm.nih.gov/pubmed/26694327.