A stem cell–centric antioxidant for Anti-Aging and Longevity: CyanthOx™

Aging, known as an inevitable process of our life. However, studies has found the possibility as the ultimate solution for for aging – Stem Cell activation. Every day, our cells face stress from metabolism, inflammation, and environmental factors. Stem cells are the body’s repair crew. As we get older, some pools shrink and most become less efficient at dividing, turning into the right cell types, and responding to stress. This decline in number and responsiveness is called stem cell exhaustion and is recognized as a hallmark of aging.

Why stem cells matter?
Stem cells are the source of fresh, healthy cells for tissues like blood, muscle, bone, skin, and blood vessels. They’re the scriptwriters of regeneration: when they’re active and well‑directed, tissue repair is faster and more accurate. When they’re tired or misdirected, healing is slower, and aging signs accelerate.

How stem cells underpin regeneration

The biology:

Stem cells and progenitors orchestrate renewal across blood, vascular, muscle, immune, skin, and connective tissues. With age, pools contract and responsiveness declines (stem cell exhaustion), impairing mobilization, differentiation, and tissue homing.

 The three essential phases in the body’s natural healing response:

  1. Mobilization—calling stem/progenitors into circulation when needed.

  2. Communication—supporting signaling that guides cell fate and tissue repair.

  3. Preservation—defending cellular machinery (mitochondria, redox, epigenetic programs) to sustain regenerative potential.

How ingredients can help slow aging via stem cells:

Stem cell–activation ingredients offer a practical, non-invasive way to help slow aspects of aging by supporting the body’s own repair programs. The idea aligns with a key hallmark of aging: stem cell exhaustion—declining numbers and responsiveness of stem/progenitor cells that maintain tissues.

  1. Mobilization (fast “readiness”):

    Certain botanicals can transiently increase circulating stem/progenitor cells, so more repair-capable cells are available when tissues signal distress. In a double-blind, placebo-controlled crossover trial, a standardized sea buckthorn extract (CyanthOx™) increased several types of circulating regenerative cells within 1–2 hours of intake.

  2. Communication (smarter repair):

    Botanicals like Astragalus and Panax notoginseng, cited in the Qualia article, modulate pathways (e.g., Notch, Wnt) and exosome messaging that guide where stem cells go and what they become—helping steer regeneration toward functional repair rather than scarring.

  3. Preservation (long-term capacity):

    High-antioxidant, mitochondria-supporting polyphenols protect stem cell niches from oxidative stress and energy decline, helping maintain stem cell identity and function with age. CyanthOx™ shows very high ORAC and in vitro protection of mitochondrial function (ATP, mitochondrial mass, nitric oxide) under oxidative stress.

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CyanthOx™ - The Strongest Plant Antioxidant

Why CyanthOx™ would be the game changer with its Stem Cell Stimulation in Aging?

Puredia’s CyanthOx™ water‑soluble, Tibetan sea buckthorn extract standardized for polyphenols, proanthocyanidins, and bioflavonoids (quercetin, kaempferol, isorhamnetin). It delivers exceptional antioxidant power and rapid stem cell mobilization—two pillars of regenerative, performance, and healthy‑aging formulas.

Stem cell exhaustion and impaired signaling—recognized hallmarks of aging—contribute to slower repair, reduced tissue resilience, and diminished performance. CyanthOx™ provides both acute support (transient stem/progenitor cell mobilization) and foundational redox balance (very high ORAC), enabling differentiated “regenerate, not just protect” positioning.

Clinically-Proven Anti Aging Formula:

  • Mobilization

    In a randomized, double‑blind, placebo‑controlled, cross‑over human trial, CyanthOx™30 acutely increased circulating progenitor and stem‑like cells within 1–2 hours of intake, including endothelial and mesenchymal lineages implicated in vascular maintenance and tissue repair.

  • Design: 12 healthy adults; 500 mg CyanthOx™30; 2‑hour window.

  • Outcome: Significant increases in progenitor, endothelial, and mesenchymal stromal cells versus placebo.

  • Preservation and cellular energy: In vitro work shows CyanthOx™ enhances mitochondrial function and cellular energetics under oxidative stress.

    • Model: RAW 264.7 cells pretreated with CyanthOx™80 (25–100 μg/mL), then H2O2 challenge.

    • Results: ATP +91%, mitochondrial mass +69%, nitric oxide +96%—supporting mitochondrial resilience and vascular signaling.

    • Reference: Liu et al., 2022 (Frontiers).

  • Antioxidant capacity: Extremely high ORAC validates potent radical scavenging and redox buffering for stem cell niches and endothelium.

    • ORAC: 895,281 μmol TE/100 g (Eurofins; Puredia report, 2019).

    • Benchmarking: ~9× grape seed extract (Superfoodly, 2019) and ~2× French maritime pine bark extract (Legault et al., 2013).

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Applications and product archetypes

  • Longevity/healthy aging:

    • Claim anchors: supports stem cell mobilization; supports cellular energy and mitochondrial function; powerful antioxidant for healthy aging.

    • Stack: CyanthOx™ + nicotinamide riboside/NMN alternative + spermidine + magnesium for cellular maintenance programs.

  • Vascular and circulation support:

    • Rationale: Endothelial progenitor mobilization + NO signaling + strong antioxidant protection of endothelium.

    • Formats: RTD shots or sachets for daily circulation routine; combine with polyphenols (e.g., grape skin), vitamin C, and citrus bergamot as allowed.

  • Sports performance and recovery:

    • Pre/post workout: acute mobilization for repair readiness; mitochondrial/NO support for performance and recovery.

    • Stack: CyanthOx™ + creatine + betaine + collagen peptides (soft‑tissue support).

  • Beauty‑from‑within:

    • Regenerative angle: stem/progenitor support + antioxidant protection of dermal matrix; pairs with Omega‑7 (Omegia™) for barrier lipids and hydration.

    • Format: daily stick packs; CyanthOx™ + Omegia™ + vitamin C + hyaluronic acid.

Upgrade Your Product Formula

CyanthOx™ bridges two high‑value mechanisms—acute stem/progenitor mobilization and robust antioxidant/mitochondrial support—into a single, water‑soluble, formulation‑ready ingredient. It enables clear, differentiating claims for longevity, vascular health, sports recovery, and beauty‑from‑within, with human clinical evidence and best‑in‑class ORAC data to power your dossier. If you’re building the next wave of regeneration‑focused supplements, CyanthOx™ is a scalable, science‑backed cornerstone.

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Featured Ingredient

Strongest Plant Antioxidants: 9x Stronger than Grape Seed & Acai

100% Plant-based & Vegan
No Additives / Solvent Used
Completely soluble in water
Good Thermal & pH Stability
Patented Technology

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References

  1. Lopez-Otin et al., 2023, Cell, 186(1), 243-278.

  2. Liu et al., 2022, Frontiers in Pharmacology, 13, Article 914146.

  3. Lin et al., 2022, Frontiers in Nutrition, 9, Article 850076.

  4. Liu et al., 2022, Antioxidants, 11(11), 1900.

  5. Drapeau et al., 2019, Clinical Interventions in Aging, 14, 253-263.

  6. Y. et al., 2016, Nutrients, 8(5), p. 245.

  7. Huang et al., 2008, Journal of Chongqing Medicine University, 33(8), pp.970-1002.

  8. Huang et al, 2008, Acta Academiae Medicinae Militaris Tertiae, 30(8), pp.771-772.

  9. Huang et al, 2008, Chinese Traditional Patent Medicine, 30(5), pp.632-635.

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