SEA BUCKTHORN leaf may support weight management*

Design: Randomised, controlled trial was conducted in 32 4-week-old mice. The mice were either fed with a normal diet with 5% corn oil (Normal Diet Group), a high-fat diet with 3% corn oil and 18% lard (High Fat Diet Group), a high-fat diet with 1% sea buckthorn leaf (SBL) (1% SBL Group) or 5% SBL (5% SBL Group) for 6 weeks.

Method and Material: Oral intake of a high-fat diet with 1% SBL or 5% SBL for 6 weeks.

Result:

• Hepatic lipid accumulation was reduced.

Hepatic Lipid Droplet Reduction

Normal Diet group

High Fat Diet group

5% SBL GRoUP

• Body weight gain was reduced by 23%, visceral fat was reduced by 25%, and fecal triglyceride excretion was increased by 117% and cholesterol excretion was increased by 53%, when comparing the treatment group with the high fat diet group.

Body Weight Gain

Visceral Fat

fecal lipid excretion

Conclusion: Sea Buckthorn leaf has anti-visceral obesity and antioxidant effects mediated by the regulation of lipid and antioxidant metabolism. It may prevent hepatic damage by enhancing the antioxidant defense system and attenuation microsomal CYP2E1 induction.

SEA BUCKTHORN Leaf may relieve constipation*

Design: Randomised, controlled trial was conducted in 100 healthy mice weighing from 17.5 to 19g. The mice were fed with 5mg/kg BW Diphenoxylate to simulate constipation and treated with water for normal and constipated group, 0.7g/kg, 1.4g/kg and 2.1g/kg sea buckthorn leaf tea (SBT) for the treatment groups for 10 days.

Method and Material: Oral intake of 0.7g/kg, 1.4g/kg and 2.1g/kg SBT for the treatment groups for 10 days.

Result: Bowel movement was increased by 40%, intestinal transit time was shorten by 41%, and fecal weight was increased by 33%, when comparing the treatment group with the constipated group.