Next Generation of Antioxidant

CyanthOx™ Sea Buckthorn Proanthocyanidins Logo

What is CyanthOx™?

CyanthOx™ is extracted from an ancient plant grown in Tibetan Plateau called sea buckthorn. Through billion years of evolution, sea buckthorn is a treasure of bioactive nutrients. CyanthOx™ water-soluble extract is a unique and rich combination of polyphenols, proanthocyanidins, bioflavonoids, which offer extensive natural health benefits.


Extraction Ratio

CyanthOx™ is obtained from sea buckthorn by using Patented Extraction Technology. It takes 300kg of sea buckthorn to produce 1kg of CyanthOx™.

CyanthOx™ has an extraction ratio of 300:1.


Shown by the HPLC on the right, the main flavonoids found in CyanthOx™ are:

  • Quercetin

  • Kaempferol

  • Isorhamnetin

High Performance Liquid Chromatogram(HPLC) of CyanthOx™

High Performance Liquid Chromatogram(HPLC) of CyanthOx™


ORAC Comparison

ORAC (μmol TE/100g)

As a result of its rich antioxidant profile, CyanthOx™ is very potent in terms of antioxidant capability.

According to Oxygen Radical Absorbance Capacity (ORAC) analysis*, CyanthOx™ has an ORAC value of 895,281 μmol TE/100g (Puredia Corporation Limited, 2019).

In comparison, CyanthOx™ is 8 times stronger than grape seed extract (, 2019) and 1.7 times more potent french maritime pine bark extract (Legault et al., 2013).

*a method of measuring antioxidant capacities in biological samples


CyanthOx™ is 1.7 Times Stronger than French Pine Bark Extract

ORAC Comparison  |  Tested by eurofins


 Mechanism of Action

CyanthOx™ Sea Buckthorn Proanthocyanidins contributes to anti-inflammation by suppressing the NF-kB pathway, inhibiting the MAPK pathway, and activating Nrf2. These anti-inflammatory pathways inhibit COX-2 activity and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) production.
  1. NF-kB Pathway leads to cell death and inflammation.

  2. MAPK Pathway leads to cell death, inflammation and tissue remodeling.

  3. Nrf2 Pathway facilitates the expression of the cell-protective gene in response to oxidative stress and inhibits inflammation enzymes and cytokines.


Clinical Trial

A clinical study recently published in Clinical Interventions in Aging shows that CyanthOx™30 can stimulate 3 different types of stem cell, contributing to anti-aging, anti-inflammation, skin health, vessel health and blood circulation.


Design: Randomized, placebo-controlled, double-blinded, cross-over trial was conducted in 12 participants for 2 hours.

Dosage: 500mg CyanthOx™30 per day

Result: Consumption of sea buckthorn proanthocyanidins leads to an increase in the following stem cells:

  • Progenitor stem cell

  • Endothelial stem cell

  • Mesenchymal stromal cell

Conclusion: 500mg CyanthOx™30 (150mg sea buckthorn proanthocyanidins) stimulates 3 different types of stem cell and supports preventive health, regenerative health, and postponing the aging process.

(Drapeau, Benson and Jensen, 2019)


Health Benefit



Skin Care


Eyes and Vision




CyanthOx™ Sea Buckthorn Proanthocyanidins Product Shot
  • Certified with the following:

CyanthOx™ Sea Buckthorn Proanthocyanidins Certifications (USDA Organic, EU Organic, Non-GMO, Halal, Kosher, NSF GMP, ISO9001, ISO14001, ISO22000, BRC certificate)

Recommended Daily Dosage: 500mg / 300mg / 187.5mg / 158mg per day

Shelf-Life: 3 years


Finished product is also available.


Technical Document

Product Brochure


CyanthOx™ Sea Buckthorn Proanthocyanidins Specification

Regulatory Information

CyanthOx™ Sea Buckthorn Proanthocyanidins Quality and Regulatory Information


  1. Puredia Corporation Limited. (2019). CyanthOx™80 ORAC Analytical Report. Available at: Here.

  2. (2019). Antioxidant ORAC Value: Grape Seed Extract. [online] Available at:

  3. Legault, J., Girard-Lalancette, K., Dufour, D. and Pichette, A. (2013). Antioxidant Potential of Bark Extracts from Boreal Forest Conifers. Antioxidants, [online] 2(3), pp.77-89. Available at:

  4. Drapeau, C., Benson, K. and Jensen, G. (2019). <p>Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (<em>Hippophae</em>) in healthy human subjects</p>. Clinical Interventions in Aging, [online] Volume 14, pp.253-263. Available at:

  5. Sugimura, R., Jha, D., Han, A., Soria-Valles, C., da Rocha, E., Lu, Y., Goettel, J., Serrao, E., Rowe, R., Malleshaiah, M., Wong, I., Sousa, P., Zhu, T., Ditadi, A., Keller, G., Engelman, A., Snapper, S., Doulatov, S. and Daley, G. (2017). Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature, [online] 545(7655), pp.432-438. Available at:

  6. Yoder, M. (2017). Endothelial stem and progenitor cells (stem cells): (2017 Grover Conference Series). Pulmonary Circulation, [online] 8(1), p.204589321774395. Available at:

  7. Goldberg, A., Mitchell, K., Soans, J., Kim, L. and Zaidi, R. (2017). The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review. Journal of Orthopaedic Surgery and Research, [online] 12(1). Available at:

  8. Keating, A. (2006). Mesenchymal stromal cells. Current Opinion in Hematology, [online] 13(6), pp.419-425. Available at: