Digestive.+iStock-154946498+%282%29.jpg

Gastrointestinal

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Cyanthox™ Promotes gastric mucosal healing

Design: Randomized, double-blinded, placebo-controlled trial was conducted in 80 participants diagnosed with Chronic Gastritis aged between 17 - 64 years old

Dosage: Oral intake of 3 x 250mg sea buckthorn proanthocyanidins(SBOPC) or 2 x 1g placebo (Amoxicillin) per day for 1 month

Result:

  • 10% more overall improvement than Amoxicillin

    • 22% more reduction in apoptotic index of the gastric mucosal epithelial cell than Amoxicillin

    • 11% more participants turn from Helicobacter Pylori positive to negative than Amoxicillin

 
CyanthOx™ is a unique sea buckthorn extract with a rich combination of  polyphenols ,  proanthocyanidins ,  bioflavonoids , which offer extensive natural health benefits.

CyanthOx™ is a unique sea buckthorn extract with a rich combination of polyphenols, proanthocyanidins, bioflavonoids, which offer extensive natural health benefits.

overall Efficacy

cyanthox health benefit gastrointestinal gastric overall.png

Apoptotic index

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Helicobacter Pylori

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Conclusion: Sea buckthorn proanthocyanidins promote peptic ulcer healing by killing H. pylori. The mechanism was suggested to be reducing the gastric mucosa expression of PAF (Platelet-activating factor, a mediator of allergic and inflammatory processes) and increase the expression of MK (Midkine, a protective factor of the gastric mucosa).

 

(Huang et al., 2008)


 
CyanthOx Gastrointestinal Intestinal Mucosal.png

Cyanthox™ Promotes intestinal mucosal healing

Design: Randomized, double-blinded, placebo-controlled trial was conducted in 120 participants diagnosed with Ulcerative Colitis aged between 17 – 74 years old

Dosage: Oral intake of 4 x 10mL sea buckthorn proanthocyanidins extract (Solid Concentration: 0.5g/mL)(SBOPC) or 4 x 1g placebo (Sulfasalazine) per day for 4 weeks

Result:

  • 16% more overall improvement than Sulfasalazine

    • Increases pS2 Expression by 82%

    • Increases Superoxide Dismutase (SOD) by 69%

    • Reduces Malondialdehyde (MDA) by 60%

Overall Efficacy

cyanthox health benefit gastrointestinal intestinal overall.png

ps2 expression

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SOD & MDA

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Conclusion: Sea buckthorn proanthocyanidins promotes gastric mucosal by increasing pS2 expression, which reduces gastric mucosal epithelial cell death. It also increases SOD and reduces MDA, reducing damages by free radicals.

 

(Huang et al., 2008)


CyanthOx Gastrointestinal Peptic Ulcer.png

Cyanthox™ Promotes peptic ulcer healing and prevents its occurrence

Design: Randomized, double-blinded, placebo-controlled trial was conducted in 72 participants diagnosed with Peptic Ulcer aged between 18 – 65 years old

Dosage: Oral intake of 3 x 500mg sea buckthorn proanthocyanidins extract capsule(SBOPC) or 2 x 0.15g placebo (Ranitidine) per day for 4 weeks

Result:

  • Similar overall performance as Ranitidine

    • 43% more increase in Hexosamine than Ranitidine

    • 26% more increase in Phospholipid than Ranitidine

    • 45% increase in Intestinal Trefoil Peptides positive (ITF+) expression rate.

    • 77% increase in pS2 expression.

 

Overall Efficacy

cyanthox health benefit gastrointestinal peptic overall.png

Hexosamine

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phospholipid

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Conclusion: Sea buckthorn proanthocyanidins promote peptic ulcer healing by increasing the synthesis of hexosamine and phospholipid, which improves gastric mucosal hydrophobicity. It also increases ITF+ and pS2 expressions, which reduces gastric mucosal epithelial cell death.

 

(Huang et al., 2008)


Reference

  1. Huang, G., Yang, Z., You, Y., Xu, L., Huang, Y. and Tang, L. (2008). Observe the possible mechanisms of sea buckthorn proanthocyanidins (SBPC) treat gastritis and study the relationship with apoptosis. Journal of Chongqing Medicine University, [online] 33(8), pp.970-1002. Available at: http://xueshu.baidu.com/usercenter/paper/show?paperid=fa0d5b51247bcb89a1615fba0474f36f&site=xueshu_se&hitarticle=1.

  2. Huang, G., Huang, Y., Huang, D., Xiao, M. and Tang, L. (2008). Therapeutic effect of Sea Buckthorn Proanthocyanidins on Ulcerative Colitis. Acta Academiae Medicinae Militaris Tertiae, [online] 30(8), pp.771-772. Available at: http://xueshu.baidu.com/usercenter/paper/show?paperid=b978c267592f20a133b670a03c9bf0cc.

  3. Huang, G., Huang, Y., Huang, D., Xiao, M., Tang, L. and Zhao, J. (2008). Study of the Sea Buckthron Proanthocyanidins (SBPC) Potential Mechanism against Peptic Ulcer. Chinese Traditional Patent Medicine, [online] 30(5), pp.632-635. Available at: http://xueshu.baidu.com/usercenter/paper/show?paperid=468b4285d733743a876bf16003235396&site=xueshu_se.