PUREDIA SEABERRY® PROANTHOCYANIDINS
Naturally found in plants, antioxidants are responsible for the vibrant colors of many flowers and fruits, including Puredia SeaBerry® Proanthocyanidins are one of 3 groups of antioxidants found in Sea Buckthorn. They are part of the polyphenols family that is known for its ability to remove harmful free oxygen radicals from cells induced by the body, stress, and the environment. Studies indicate that the antioxidant power of proanthocyanidins is 20 times higher than that of vitamin C and 50 times higher than vitamin E.
Research suggests that these compounds are beneficial in many health related areas because of their ability to bond with collagen, therefore promoting youthful skin, cell health, elasticity, and flexibility. Other studies have shown that proanthocyanidins help protect the body from UV ray damage, light-induced eye degeneration and improve blood circulation by strengthening capillaries, arteries, and veins.
Not all antioxidants are created equal. Although the proanthocyanidins in products like grape seed extract can be as high as 95%, the ORAC is only around 108,130.
Sea Buckthorn seed PACs significantly attenuated the destruction of electroretinograms and maintained the retinal structure after 7 days of light exposure. Increased retinal photooxidative damage was expressed by the depletion of glutathione peroxidase and catalase activities, the decrease of total antioxidant capacity level and the increase of malondialdehyde level. Light exposure induced a significant increase of inflammatory cytokines (IL-1 , TNF- and IL-6) and angiogenesis (VEGF) levels in retina. Light exposure upregulated the expression of pro-apoptotic proteins Bax and caspase-3 and downregulated the expression of anti-apoptotic protein Bcl-2. However, sea buckthorn seed PACs ameliorated these changes induced by light exposure. Sea buckthorn seed PACs mediated the protective effect against light-induced retinal degeneration via antioxidant, anti-inflammatory and antiapoptotic mechanisms. Sea Buckthorn OPC restored the retina thickness by 25% when compared to the non-treated group.
1. Wang, Y., et al., Protective Effect of Proanthocyanidins from Sea Buckthorn (Hippophae Rhamnoides L.) Seed against Visible Light-Induced Retinal Degeneration in Vivo. Nutrients, 2016. 8(5).
2. Belcaro, G., et al., Grape seed procyanidins in pre- and mild hypertension: a registry study. Evid Based Complement Alternat Med, 2013. 2013: p. 313142.
3. Oligomeric proanthocyanidins (OPCs). Monograph. Altern Med Rev, 2003. 8(4): p. 442-50.